Service
cryoEM
cryoEM | FairJourney Biologics
Whether you're using our stand-alone cryoEM services or integrating structure determination into a broader discovery and development campaign at FairJourney Biologics, we deliver:
- Speed – High-resolution maps and atomic models of your protein, antibody–protein, or ligand–protein complex in as little as 3 weeks*.
- Quality – Expertly reconstructed density maps and validated, deposition-ready structural models.
- Insight – In-depth analysis of protein structure, key residue interactions, and molecular dynamics.
- Efficiency – Seamless handoff of structural data for structure-based design of next-generation synthetic libraries.
*if initial screening is passed successfully
From structural validation of protein designs to epitope mapping your lead therapeutic, our state-of-the-art cryoEM platform delivers the structural insights needed to advance your pipeline with confidence.
With the advancements in cryoEM and computational protein design, protein structure determination has become a critical component of biologics discovery and development, from validating early therapeutic candidates to generating valuable data for IND applications. As part of our continued commitment to being your end-to-end partner in antibody discovery and development, we’ve now added cryoEM to our list of services, delivering actionable structural insights that accelerate and de-risk development.
Our dedicated team brings over 40 years of combined expertise in cryoEM-based structure determination of proteins, antibody-protein and ligand-protein complexes. CryoEM adds value to any stage of the development pipeline, and we’re equipped to support your needs, from structural characterization of your target protein to high-resolution, regulatory-grade epitope mapping of your therapeutic candidates.
The solution if you need rapid, coarse-grained structural insights (resolutions >3.8 Å). Our intermediate-resolution screening service enables fast, cost-effective structural evaluation making it perfect for early-stage decision making. Use it to triage epitope diversity in antibody panels or immune libraries, identify oligomeric states and conformational variability of your target, or determine whether your sample is suitable for high-resolution cryoEM.
Whether it’s a protein, protein–protein, or protein–ligand complex our high-resolution structure determination service provides the atomic-level clarity needed to understand binding interfaces, mechanisms of action, and molecular function. Leverage these high-resolution models for structure-guided redesign, rational optimization, and informed lead selection, giving you the insight and control to drive scientific discovery and therapeutic development with confidence.
Capture the dynamic nature of your protein complex. Our advanced data processing workflows allows intermediate-to-high-resolution visualization of conformational states across functional cycles, binding events, or allosteric transitions. By visualizing heterogeneity directly from cryoEM data, you gain insights into its flexibility, intermediate states, and targetable conformations that inform rational drug or binder design.
Design smarter libraries with structure at the core. Using our structure-based library design pipeline that encompasses molecular dynamics simulations, physics- and machine-learning based algorithms, we build libraries tailored to your protein’s binding surface, conformational landscape, or functional hotspots. Whether you're engineering paratopes, humanizing an antibody, or stabilizing a protein conformation, structure-based design increases the chance of identifying functional hits while reducing screening burden.