Service
Cryo-EM
cryoEM | FairJourney Biologics
Whether you're using our stand-alone cryo-EM services or integrating structure determination into a broader discovery and development campaign at FairJourney Biologics, we deliver:
- Speed – High-resolution maps and atomic models of your protein, antibody–protein, or ligand–protein complex in as little as 3 weeks (if initial screening is passed successfully).
- Quality – Expertly reconstructed density maps and validated, deposition-ready structural models.
- Insight – In-depth analysis of protein structure, key residue interactions, and molecular dynamics.
- Efficiency – Seamless handoff of structural data for structure-based design of next-generation synthetic libraries.
From structural validation of protein designs to epitope mapping your lead therapeutic, our state-of-the-art cryo-EM platform delivers the structural insights needed to advance your pipeline with confidence.
With the advancements in cryo-EM and computational protein design, protein structure determination has become a critical component of biologics discovery and development, from validating early therapeutic candidates to generating valuable data for IND applications. As part of our continued commitment to being your end-to-end partner in antibody discovery and development, we’ve now added cryo-EM to our list of services, delivering actionable structural insights that accelerate and de-risk development.
Our dedicated team brings over 40 years of combined expertise in cryo-EM-based structure determination of proteins, antibody-protein and ligand-protein complexes. Cryo-EM adds value to any stage of the development pipeline, and we’re equipped to support your needs, from structural characterization of your target protein to high-resolution, regulatory-grade epitope mapping of your therapeutic candidates.
Gain molecular insight into binding interfaces, conformational dynamics, and mechanisms of action with our Structure Validation service. From confirming target integrity and binding pocket accessibility to guiding structure-based design and optimization, we provide the atomic-level clarity needed to make confident, data-driven decisions. Whether determining the structure of a standalone protein or a small molecule–protein complex, our high-resolution models accelerate and de-risk therapeutic development.
- Requirement: Purified protein, protein-protein or protein-ligand complex
- Timeline: <4 weeks
Use our Epitope Mapping service to get rapid molecular details of the epitope-paratope interface of your antibody, VHH or scFv. Leverage structural information of your therapeutic candidate and its binding site to understand target specificity and mechanism of action. In parallel, gain the structural framework needed for a seamless transition to in silico affinity maturation using our Structure-Based Design service.
- Requirement: Purified antibody-protein complex (Fab, VHH, or scFv)
- Timeline: <4 weeks
Lead selection from a panel of antibody candidates can be a laborious and complex process. Use our Multiplex Mapping service to enable rapid, high-resolution, structure-based lead selection from a panel of up to 10 candidates. Using a combination of advanced data processing tools and AI, we give you the atomic-level information to downselect and prioritize — all derived from a single imaging session. This approach delivers multiple epitope–paratope structures from one cryo-EM map, dramatically accelerating your discovery timelines.
- Requirement: Purified complex of protein with multiple antibodies (Fab, VHH, or scFv)
- Timeline: <6 weeks
Understanding the epitope diversity within the polyclonal antibody response of your vaccinated animal enables early de-risking of antibody discovery campaigns.
Our Serum Antibody Triage service provides a clear intermediate-resolution map of the epitope landscape from purified polyclonal serum antibodies, giving you the insight to prioritize targets or samples and the confidence to proceed with our Epitope-Based Hit Discovery service.
- Requirement: Purified complex of protein with polyclonal antibody (Fab or VHH)
- Timeline: <6 weeks
Transform your antibody discovery pipeline by using a structure-first approach! Our Epitope-Based Hit Discovery service builds from our Serum Antibody Triage service and uses an AI-based workflow that incorporates high resolution maps of polyclonal antibodies and NGS sequencing of (sorted) B cells. By enabling direct and structure-based selection of epitope-specific, high-affinity antibodies from an NGS dataset, our Epitope-Based Hit Discovery service provides informed and accelerated discovery of desired antibodies.
- Requirement: NGS dataset form (sorted) B cells, high-resolution map from our Serum Antibody Triage service
- Timeline: <4 weeks (including production and screening of sequences)
Using an ensemble of physics-based and AI-based methods, our Structure-Based Design service performs computational, structure-informed redesign of your protein or antibody. Unlock structure-guided affinity maturation, antibody humanization or protein stabilization that seamlessly integrates with our high-throughput production and screening pipeline. With only 6 weeks from structure to screening this service provides dramatically shorter timelines than traditional library-based workflows.
- Requirement: Protein model
- Timeline: <6 weeks (including production and screening of designs)