MultiPath Discovery

MultiPath Discovery

Antibody Discovery. Any Target. Any Format

A format-agnostic platform configured for your target biology and built for clinical success. FairJourney Bio designs each campaign backwards from your Target Product Profile — then executes it with the integrated depth of a full discovery-to-IND CRO.

Antibody Discovery. Any Target. Any Format

A format-agnostic platform configured for your target biology and built for clinical success. FairJourney Bio designs each campaign backwards from your Target Product Profile — then executes it with the integrated depth of a full discovery-to-IND CRO.

Antibody Discovery. Any Target. Any Format

A format-agnostic platform configured for your target biology and built for clinical success. FairJourney Bio designs each campaign backwards from your Target Product Profile — then executes it with the integrated depth of a full discovery-to-IND CRO.

>1,400

projects completed

>250

Global partners

>19

assets in clinical development

2

assets in Phase III

Start With the End in Mind

Most discovery platforms give you a workflow. MultiPath Discovery gives you a strategy. Before a single panning round begins, our scientific lead designs the optimal combination of diversity source, screening platform, and molecular format for your specific target and Target Product Profile.

The result: higher hit rates, better developability profiles, and a lead series that is ready for the next stage of your programme.

Solutions for Every Application

  • Bispecific and multispecific antibodies

  • Internalising mAbs for ADC programmes

  • pH-selective binders

  • Dual binders

  • TCR mimetics

  • CAR constructs

  • Fc isotype variants and engineered Fc mutants

  • Tool antibodies for target validation

  • VHH nanobodies and VHH-Fc fusions

  • Anti-idiotype antibodies and clinical assay tools

  • Biomarker detection and sandwich pairs

Solutions for Every Application

  • Bispecific and multispecific antibodies

  • Internalising mAbs for ADC programmes

  • pH-selective binders

  • Dual binders

  • TCR mimetics

  • CAR constructs

  • Fc isotype variants and engineered Fc mutants

  • Tool antibodies for target validation

  • VHH nanobodies and VHH-Fc fusions

  • Anti-idiotype antibodies and clinical assay tools

  • Biomarker detection and sandwich pairs

Solutions for Every Application

  • Bispecific and multispecific antibodies

  • Internalising mAbs for ADC programmes

  • pH-selective binders

  • Dual binders

  • TCR mimetics

  • CAR constructs

  • Fc isotype variants and engineered Fc mutants

  • Tool antibodies for target validation

  • VHH nanobodies and VHH-Fc fusions

  • Anti-idiotype antibodies and clinical assay tools

  • Biomarker detection and sandwich pairs

One CRO. All the Way to IND

MultiPath Discovery feeds directly into FairJourney Bio's integrated development capability. One project lead. One data thread. No handoffs, no gaps between stages.

A Modular Architecture for Every Target

The Platform

MultiPath Discovery is built around three independent axes — source of diversity, discovery platform, and final molecular format. For every project, our scientific leads select the combination that gives your programme the best probability of delivering a clinical candidate.

A Modular Architecture for Every Target

The Platform

MultiPath Discovery is built around three independent axes — source of diversity, discovery platform, and final molecular format. For every project, our scientific leads select the combination that gives your programme the best probability of delivering a clinical candidate.

A Modular Architecture for Every Target

The Platform

MultiPath Discovery is built around three independent axes — source of diversity, discovery platform, and final molecular format. For every project, our scientific leads select the combination that gives your programme the best probability of delivering a clinical candidate.

Axis 1 — Sources of Diversity

The starting diversity determines what is discoverable. MultiPath Discovery provides access to three distinct repertoire types, each optimised for a different scientific objective.

Naïve — Broadest coverage. Any target

Sourced from unimmunised human donors and llamas. Ideal for targets with low immunogenicity or close homology to self-antigens. Library diversity >10¹⁰ clones in ScFv, Fab, and VHH formats. κ and λ light chains. Common light chain available.

Semi-Synthetic — Engineered for developability

Human donor frameworks combined with computationally optimised synthetic CDR design. Developability is selected at the library level — before a single clone is characterised. Library diversity up to 10¹¹ clones. Proprietary Cosmic Library and SuperHuman 2.0.

Immune — Highest affinity. Maximum potency

Antigen-experienced repertoires from immunised animals or human patients. Library diversity 10⁶–10⁹ clones in ScFv, Fab, and IgG formats. Multiple species supported, including mice, rabbits, llamas, and human patients. Recovery by phage display and single B-cell.

NEW - fully human antibody transgenic mice - Abtherx ™ partnership - integrated with our B-Cell navigator platform.

Axis 1 — Sources of Diversity

The starting diversity determines what is discoverable. MultiPath Discovery provides access to three distinct repertoire types, each optimised for a different scientific objective.

Naïve — Broadest coverage. Any target

Sourced from unimmunised human donors and llamas. Ideal for targets with low immunogenicity or close homology to self-antigens. Library diversity >10¹⁰ clones in ScFv, Fab, and VHH formats. κ and λ light chains. Common light chain available.

Semi-Synthetic — Engineered for developability

Human donor frameworks combined with computationally optimised synthetic CDR design. Developability is selected at the library level — before a single clone is characterised. Library diversity up to 10¹¹ clones. Proprietary Cosmic Library and SuperHuman 2.0.

Immune — Highest affinity. Maximum potency

Antigen-experienced repertoires from immunised animals or human patients. Library diversity 10⁶–10⁹ clones in ScFv, Fab, and IgG formats. Multiple species supported, including mice, rabbits, llamas, and human patients. Recovery by phage display and single B-cell.

NEW - fully human antibody transgenic mice - Abtherx ™ partnership - integrated with our B-Cell navigator platform.

Axis 1 — Sources of Diversity

The starting diversity determines what is discoverable. MultiPath Discovery provides access to three distinct repertoire types, each optimised for a different scientific objective.

Naïve — Broadest coverage. Any target

Sourced from unimmunised human donors and llamas. Ideal for targets with low immunogenicity or close homology to self-antigens. Library diversity >10¹⁰ clones in ScFv, Fab, and VHH formats. κ and λ light chains. Common light chain available.

Semi-Synthetic — Engineered for developability

Human donor frameworks combined with computationally optimised synthetic CDR design. Developability is selected at the library level — before a single clone is characterised. Library diversity up to 10¹¹ clones. Proprietary Cosmic Library and SuperHuman 2.0.

Immune — Highest affinity. Maximum potency

Antigen-experienced repertoires from immunised animals or human patients. Library diversity 10⁶–10⁹ clones in ScFv, Fab, and IgG formats. Multiple species supported, including mice, rabbits, llamas, and human patients. Recovery by phage display and single B-cell.

NEW - fully human antibody transgenic mice - Abtherx ™ partnership - integrated with our B-Cell navigator platform.

Axis 2 — Discovery Platforms

Each diversity source can be screened using one or more of four orthogonal platforms — selected based on your target, format, and functional requirements. Full detail in the Discovery Platforms tab.


  • Phage Display — broadest library access, fastest timelines: 6–8 weeks

  • Mammalian Display — developability-linked, patent-protected: 8–10 weeks

  • Yeast Display — quantitative FACS multi-parameter selection: 8–10 weeks

  • Single B-Cell — natively paired VH-VL from human patients and mice: 8–10 weeks

Axis 2 — Discovery Platforms

Each diversity source can be screened using one or more of four orthogonal platforms — selected based on your target, format, and functional requirements. Full detail in the Discovery Platforms tab.


  • Phage Display — broadest library access, fastest timelines: 6–8 weeks

  • Mammalian Display — developability-linked, patent-protected: 8–10 weeks

  • Yeast Display — quantitative FACS multi-parameter selection: 8–10 weeks

  • Single B-Cell — natively paired VH-VL from human patients and mice: 8–10 weeks

Axis 2 — Discovery Platforms

Each diversity source can be screened using one or more of four orthogonal platforms — selected based on your target, format, and functional requirements. Full detail in the Discovery Platforms tab.


  • Phage Display — broadest library access, fastest timelines: 6–8 weeks

  • Mammalian Display — developability-linked, patent-protected: 8–10 weeks

  • Yeast Display — quantitative FACS multi-parameter selection: 8–10 weeks

  • Single B-Cell — natively paired VH-VL from human patients and mice: 8–10 weeks

Axis 3 — Final Format

Campaigns are configured to deliver leads in your required final format from day one. No reformatting. No re-characterisation.


  • IgG1, IgG2, IgG4 and engineered Fc variants

  • Fab, scFv

  • VHH nanobody and VHH-Fc fusion

  • Biparatopic VHH

  • Bispecific and multispecific formats

  • Common light chain for bispecific assembly

Axis 3 — Final Format

Campaigns are configured to deliver leads in your required final format from day one. No reformatting. No re-characterisation.


  • IgG1, IgG2, IgG4 and engineered Fc variants

  • Fab, scFv

  • VHH nanobody and VHH-Fc fusion

  • Biparatopic VHH

  • Bispecific and multispecific formats

  • Common light chain for bispecific assembly

Axis 3 — Final Format

Campaigns are configured to deliver leads in your required final format from day one. No reformatting. No re-characterisation.


  • IgG1, IgG2, IgG4 and engineered Fc variants

  • Fab, scFv

  • VHH nanobody and VHH-Fc fusion

  • Biparatopic VHH

  • Bispecific and multispecific formats

  • Common light chain for bispecific assembly

Libraries Built for the Clinic. Exclusive to FairJourney Bio

Proprietary Libraries   

Most antibody libraries are designed to produce hits. FairJourney Bio's proprietary libraries are designed to produce drugs. Developability is hardwired into the diversity — so the clones you advance are already fit for clinical development.

Access is exclusive. No licensing. No competitor access. Lineage gatekeeping protects your programme's IP throughout.

Libraries Built for the Clinic. Exclusive to FairJourney Bio

Proprietary Libraries   

Most antibody libraries are designed to produce hits. FairJourney Bio's proprietary libraries are designed to produce drugs. Developability is hardwired into the diversity — so the clones you advance are already fit for clinical development.

Access is exclusive. No licensing. No competitor access. Lineage gatekeeping protects your programme's IP throughout.

Libraries Built for the Clinic. Exclusive to FairJourney Bio

Proprietary Libraries   

Most antibody libraries are designed to produce hits. FairJourney Bio's proprietary libraries are designed to produce drugs. Developability is hardwired into the diversity — so the clones you advance are already fit for clinical development.

Access is exclusive. No licensing. No competitor access. Lineage gatekeeping protects your programme's IP throughout.

Cosmic Library

FairJourney Bio's flagship library. 100 billion fully human scFv clones. Used in more than 70% of all Tumbler campaigns since its 2022 launch.

Architecture


  • Memory layer: natural CDRs from BCR-seq data across 100 NGS-filtered donors — memory and naïve B cells

  • Oligo layer: liability-free synthetic CDRs optimised for Tumbler CDR shuffling compatibility

  • 25 drug-worthy frameworks: 5 VH × 5 VK, 100% germline, including 16 novel frameworks

  • 100bn scFvs — virtually no clonal redundancy, improved CDR-H3 and L3 diversity

What this means for your programme


  • Verified developability from the first round of selection

  • Optimised for low immunogenicity — fully human, germline frameworks

  • Exclusive to FairJourney Bio — no licensing, lineage gatekeeping, zero competitor access

In practice: SIRPα

Target with 80% homology to cynomolgus SIRPα and 87% homology to SIRPβ. Using the Cosmic Library: 22 of 25 reformatted IgGs functional at low-nM affinity. 82% showed Tm >68°C; 86% showed Tagg >65°C. 21 distinct epitope bins identified.

Cosmic Library

FairJourney Bio's flagship library. 100 billion fully human scFv clones. Used in more than 70% of all Tumbler campaigns since its 2022 launch.

Architecture


  • Memory layer: natural CDRs from BCR-seq data across 100 NGS-filtered donors — memory and naïve B cells

  • Oligo layer: liability-free synthetic CDRs optimised for Tumbler CDR shuffling compatibility

  • 25 drug-worthy frameworks: 5 VH × 5 VK, 100% germline, including 16 novel frameworks

  • 100bn scFvs — virtually no clonal redundancy, improved CDR-H3 and L3 diversity

What this means for your programme


  • Verified developability from the first round of selection

  • Optimised for low immunogenicity — fully human, germline frameworks

  • Exclusive to FairJourney Bio — no licensing, lineage gatekeeping, zero competitor access

In practice: SIRPα

Target with 80% homology to cynomolgus SIRPα and 87% homology to SIRPβ. Using the Cosmic Library: 22 of 25 reformatted IgGs functional at low-nM affinity. 82% showed Tm >68°C; 86% showed Tagg >65°C. 21 distinct epitope bins identified.

Cosmic Library

FairJourney Bio's flagship library. 100 billion fully human scFv clones. Used in more than 70% of all Tumbler campaigns since its 2022 launch.

Architecture


  • Memory layer: natural CDRs from BCR-seq data across 100 NGS-filtered donors — memory and naïve B cells

  • Oligo layer: liability-free synthetic CDRs optimised for Tumbler CDR shuffling compatibility

  • 25 drug-worthy frameworks: 5 VH × 5 VK, 100% germline, including 16 novel frameworks

  • 100bn scFvs — virtually no clonal redundancy, improved CDR-H3 and L3 diversity

What this means for your programme


  • Verified developability from the first round of selection

  • Optimised for low immunogenicity — fully human, germline frameworks

  • Exclusive to FairJourney Bio — no licensing, lineage gatekeeping, zero competitor access

In practice: SIRPα

Target with 80% homology to cynomolgus SIRPα and 87% homology to SIRPβ. Using the Cosmic Library: 22 of 25 reformatted IgGs functional at low-nM affinity. 82% showed Tm >68°C; 86% showed Tagg >65°C. 21 distinct epitope bins identified.

SuperHuman 2.0

76 billion fully human scFv clones. An NGS-informed library where developability is engineered into every clone and genuine sequence diversity is proven, not assumed.

  • CDR-H3 and L3 from naïve repertoire — other CDRs from memory B-cell compartment

  • ~100 donor immune repertoires combined

  • Highest-frequency VH paratope = 0.03% of library — truly unique sequence space

  • CDRH3 sequences average 9.7 amino acids apart

  • Thermostability, aggregation resistance, and low immunogenicity built in

  • 5 SuperHuman-derived antibodies currently in clinical trials

SuperHuman 2.0

76 billion fully human scFv clones. An NGS-informed library where developability is engineered into every clone and genuine sequence diversity is proven, not assumed.

  • CDR-H3 and L3 from naïve repertoire — other CDRs from memory B-cell compartment

  • ~100 donor immune repertoires combined

  • Highest-frequency VH paratope = 0.03% of library — truly unique sequence space

  • CDRH3 sequences average 9.7 amino acids apart

  • Thermostability, aggregation resistance, and low immunogenicity built in

  • 5 SuperHuman-derived antibodies currently in clinical trials

SuperHuman 2.0

76 billion fully human scFv clones. An NGS-informed library where developability is engineered into every clone and genuine sequence diversity is proven, not assumed.

  • CDR-H3 and L3 from naïve repertoire — other CDRs from memory B-cell compartment

  • ~100 donor immune repertoires combined

  • Highest-frequency VH paratope = 0.03% of library — truly unique sequence space

  • CDRH3 sequences average 9.7 amino acids apart

  • Thermostability, aggregation resistance, and low immunogenicity built in

  • 5 SuperHuman-derived antibodies currently in clinical trials

Explorer Platform

Fully human ScFv, Fab, common LC and humanised VHH* libraries with selected, developability-optimised frameworks. Rapid affinity maturation by CDR cassette shuffling. The preferred tool for fast-cycle maturation without sacrificing biophysical quality.

*Early access Q1 2027

Explorer Platform

Fully human ScFv, Fab, common LC and humanised VHH* libraries with selected, developability-optimised frameworks. Rapid affinity maturation by CDR cassette shuffling. The preferred tool for fast-cycle maturation without sacrificing biophysical quality.

*Early access Q1 2027

Explorer Platform

Fully human ScFv, Fab, common LC and humanised VHH* libraries with selected, developability-optimised frameworks. Rapid affinity maturation by CDR cassette shuffling. The preferred tool for fast-cycle maturation without sacrificing biophysical quality.

*Early access Q1 2027

Full Framework Libraries

The broadest natural framework coverage available. Framework and CDR repertoires from more than 100 human donors. Separate κ and λ light chain libraries. Up to 50 billion clones per library in ScFv and Fab phage display formats.

Full Framework Libraries

The broadest natural framework coverage available. Framework and CDR repertoires from more than 100 human donors. Separate κ and λ light chain libraries. Up to 50 billion clones per library in ScFv and Fab phage display formats.

Full Framework Libraries

The broadest natural framework coverage available. Framework and CDR repertoires from more than 100 human donors. Separate κ and λ light chain libraries. Up to 50 billion clones per library in ScFv and Fab phage display formats.

Hit Rates Across Target Classes

  • Immune checkpoint (soluble): 93%

  • Virus-associated antigen: 77%

  • Tumour-associated antigen: 74%

  • Receptor tyrosine kinase: 58–79% (across library formats)

  • Transmembrane single-pass Type I: 77%

Hit Rates Across Target Classes

  • Immune checkpoint (soluble): 93%

  • Virus-associated antigen: 77%

  • Tumour-associated antigen: 74%

  • Receptor tyrosine kinase: 58–79% (across library formats)

  • Transmembrane single-pass Type I: 77%

Hit Rates Across Target Classes

  • Immune checkpoint (soluble): 93%

  • Virus-associated antigen: 77%

  • Tumour-associated antigen: 74%

  • Receptor tyrosine kinase: 58–79% (across library formats)

  • Transmembrane single-pass Type I: 77%

Discovery Platforms   

The Right Platform for Every Discovery Challenge

Platform selection is a scientific decision. FairJourney Bio operates all four major antibody screening technologies and designs multi-platform strategies when the biology demands it.

Applications

Every Modality. Validated at Scale

Over 1,400 completed projects across the full spectrum of therapeutic antibody formats. Here is how MultiPath Discovery is applied to the most common — and most complex — modalities.

Transparent from Day One

Process & Deliverables   

Every MultiPath Discovery project runs with full partner visibility. A single scientific project lead is accountable from kick-off to hit delivery — the same person who designs the strategy, reviews the data, and makes the experimental decisions.

Transparent from Day One

Process & Deliverables   

Every MultiPath Discovery project runs with full partner visibility. A single scientific project lead is accountable from kick-off to hit delivery — the same person who designs the strategy, reviews the data, and makes the experimental decisions.

Access is exclusive. No licensing. No competitor access. Lineage gatekeeping protects your programme's IP throughout.

Transparent from Day One

Process & Deliverables   

Every MultiPath Discovery project runs with full partner visibility. A single scientific project lead is accountable from kick-off to hit delivery — the same person who designs the strategy, reviews the data, and makes the experimental decisions.

Workflow

01

Scientific Alignment & Strategy Design

Target biology and Target Product Profile reviewed together. A bespoke discovery strategy is documented and shared with the partner before any work begins.

02

Antigen Preparation & Library Setup

FairJourney Bio produces antigen if not provided by the partner. Library preparation and immunisation proceed in parallel, minimising programme start time.

03

Discovery Screening

Panning rounds executed with intermediate data shared at each milestone. Strategy adjustments are made collaboratively — our scientific lead drives the experimental direction.

04

Hit Confirmation & Characterisation

Hits expressed, purified, and confirmed by ELISA and/or SPR. Sequence diversity and initial selectivity data generated and shared.

05

Data Transfer & Programme Transition

Full data package delivered. Where the programme continues within FairJourney Bio, the same project lead manages the transition — same team, same data, zero re-learning curve.

What You Receive

  • Sequence-confirmed antibody hits in your required final format

  • Binding data: affinity, selectivity, and cross-reactivity characterisation

  • Sequence diversity analysis: V-gene usage, CDR lengths, clonal family distribution

  • Intermediate report and Certificate of Analysis at each workpackage end — raw and processed data

  • Clone overview document (Excel): per-clone screening data and V-gene sequences for all hits

  • Final project report: experimental design, decision log, hit series summary

  • Full data security — your programme data is never shared across projects

How We Work

  • Science-driven — our scientific project lead calls the experimental shots

  • Collaborative — regular sync meetings, shared decision-making with your team

  • Transparent — real-time dedicated data sharing space, no black box

  • Secure — highest data security standards, fully independent programmes

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