Tumbler™

Tumbler™

One Campaign. Every Parameter. Optimised

Conventional antibody engineering is sequential, one parameter at a time. Tumbler™ does it all at once. Starting from one or a handful of lead clones, Tumbler™ builds a library of at least 500 million variants by shuffling all six CDRs simultaneously, then screens with bespoke panning strategies to optimise every objective in a single campaign.

One Campaign. Every Parameter. Optimised

Conventional antibody engineering is sequential, one parameter at a time. Tumbler™ does it all at once. Starting from one or a handful of lead clones, Tumbler™ builds a library of at least 500 million variants by shuffling all six CDRs simultaneously, then screens with bespoke panning strategies to optimise every objective in a single campaign.

One Campaign. Every Parameter. Optimised

Conventional antibody engineering is sequential, one parameter at a time. Tumbler™ does it all at once. Starting from one or a handful of lead clones, Tumbler™ builds a library of at least 500 million variants by shuffling all six CDRs simultaneously, then screens with bespoke panning strategies to optimise every objective in a single campaign.

What Tumbler™ optimises  

  • Affinity maturation — >5-fold improvement over parental demonstrated

  • Humanisation — reduce immunogenicity while expanding the lead series

  • Cross-reactivity induction — species cross-reactivity, bi-epitopic paratopes (2-in-1 binders to dissimilar targets)

  • Clinical profile enhancement — liability removal, thermostability, broaden IP coverage

Discuss with our team

What Tumbler™ optimises  

  • Affinity maturation — >5-fold improvement over parental demonstrated

  • Humanisation — reduce immunogenicity while expanding the lead series

  • Cross-reactivity induction — species cross-reactivity, bi-epitopic paratopes (2-in-1 binders to dissimilar targets)

  • Clinical profile enhancement — liability removal, thermostability, broaden IP coverage

Discuss with our team

What Tumbler™ optimises  

  • Affinity maturation — >5-fold improvement over parental demonstrated

  • Humanisation — reduce immunogenicity while expanding the lead series

  • Cross-reactivity induction — species cross-reactivity, bi-epitopic paratopes (2-in-1 binders to dissimilar targets)

  • Clinical profile enhancement — liability removal, thermostability, broaden IP coverage

Discuss with our team

Timeline

Multiparameter optimisation in as little as 4 months. Starts with a free pre-project risk assessment (~1 week).

Timeline

Multiparameter optimisation in as little as 4 months. Starts with a free pre-project risk assessment (~1 week).

Timeline

Multiparameter optimisation in as little as 4 months. Starts with a free pre-project risk assessment (~1 week).

The data  

257

unique binders from a single affinity maturation campaign (~70% hit rate)

28

clones with over 5-fold affinity improvement versus parental

>5-fold

affinity improvement on a clone previously matured at another CRO

>20

Tumbler™ campaigns completed across diverse targets and therapeutic areas

Data ownership

Clients own their Tumbler™ Library and all data generated, royalty-free. SAR data is optimal for ML training sets and AI-based optimisation models.

Data ownership

Clients own their Tumbler™ Library and all data generated, royalty-free. SAR data is optimal for ML training sets and AI-based optimisation models.

Data ownership

Clients own their Tumbler™ Library and all data generated, royalty-free. SAR data is optimal for ML training sets and AI-based optimisation models.

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